Kilcoyne, Michelle published the artcileSurface chemistry and linker effects on lectin-carbohydrate recognition for glycan microarrays, Synthetic Route of 96345-79-8, the publication is Analytical Methods (2012), 4(9), 2721-2728, database is CAplus.
Glycan microarrays are an increasingly utilized tool for anal. of protein-carbohydrate interactions and a variety of glycan-containing mols. and slide chemistries have been used to array carbohydrates on microarray surfaces. Slide surface chem. can have significant impact on the ligand presentation, background noise, spot size and morphol. and reproducibility of the arrayed mols., which in turn impacts upon lectin-carbohydrate recognition. The linker used to attach the carbohydrate to the mol. scaffold is another variable in ligand presentation. To evaluate these effects, three different microarray surface chemistries were arrayed with the same mono- and di-saccharide neoglycoconjugates and natural glycoproteins and incubated with four well-characterized plant lectins. Analogs of three monosaccharide neoglycoconjugates, with two common linkers each, were included in the test group to evaluate the linker effect on lectin recognition. Based on lowest background noise, expected lectin-ligand interaction, good spot morphol. and best reproducibility, the three-dimensional hydrogel slide surface proved most suitable for lectin interrogation of carbohydrate ligands, and the more flexible phenylisothiocyanate linker afforded greater recognition of the carbohydrates by the relevant lectins.
Analytical Methods published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Synthetic Route of 96345-79-8.
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