Gormemis, Ahmet E. published the artcileBenzofuroindole analogues as potent BKCa channel openers, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is ChemBioChem (2005), 6(10), 1745-1748, database is CAplus and MEDLINE.
New, potent, large-conductance, calcium-activated potassium-channel (BKCa) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R1 = H, Br; R2 = H, CF3, OCH3, Cl; R3 = H, COOH, COOCH3, Cl, OCH3, CF3; R4 = H, Cl, F; R5 = H, Cl, CF3; R6 = H, Cl, F, CF3) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BKCa-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R1 = R4 = R5 = H; R2 = CF3; R3 = COOH, R6 = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.
ChemBioChem published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.
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