Gestin, J. F. published the artcileIntroduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab’)2 fragments of anti-carcinoembryonic antigen antibody–I. A new reproducible synthetic method, Category: alcohols-buliding-blocks, the publication is Nuclear Medicine and Biology (1993), 20(6), 755-62, database is CAplus and MEDLINE.
The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab’)2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.
Nuclear Medicine and Biology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.
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