Freichel, Tanja published the artcileToward orthogonal preparation of sequence-defined monodisperse hetero-multivalent glyco-macromolecules on solid support using Staudinger ligation and copper-catalyzed click reactions, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2017), 82(18), 9400-9409, database is CAplus and MEDLINE.
The investigation of hetero-multivalent interactions of complex glyco-ligands and proteins is critical for understanding important biol. processes and developing carbohydrate-based pharmaceutics. Synthetic glycomimetics, derived by mimicking complex glyco-ligands on a variety of scaffolds, have become important tools for studying the role of carbohydrates in chem. and biol. In this paper, we report on a new synthetic strategy for the preparation of mono-disperse, sequence-defined glyco-oligomers or so-called precision glyco-macromols. based on solid phase oligomer synthesis and the Staudinger ligation. This strategy employs a solid-supported synthetic approach using a novel carboxy-functionalized building block which bears a functional handle required for Staudinger ligation on solid support. Furthermore, we combined Staudinger ligation and copper catalyzed azide alkyne cycloaddition (CuAAC) reactions to synthesize hetero-multivalent glyco-oligomers on solid support for the first time, demonstrating the utility of this approach for the synthesis of hetero-functional glyco-macromols.
Journal of Organic Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.
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