Enache, Teodor Adrian published the artcileElectrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes, Synthetic Route of 328-90-5, the publication is Combinatorial Chemistry & High Throughput Screening (2010), 13(7), 569-577, database is CAplus and MEDLINE.
The electrochem. behavior of triflusal (TRF) and aspirin (ASA), before and after hydrolysis in water and in alk. medium using two different electrode surfaces, glassy carbon and boron doped diamond, was studied by differential pulse voltammetry over a wide pH range. The hydrolysis products were 2-(hydroxyl)-4-(trifluoromethyl)-benzoic acid (HTB) for triflusal and salicylic acid (SA) for aspirin, which in vivo represent their main metabolites. The hydrolysis processes were also followed by spectrophotometry. The UV results showed complete hydrolysis after one hour for TRF and after two hours for ASA in alk. solution The glassy carbon electrode enables only indirect determination of TRF and ASA through the electrochem. detection of their hydrolysis products HTB and SA, resp. The oxidation processes of HTB and SA are pH dependent and involve different numbers of electrons and protons. Moreover, the difference between the oxidation peak potential of SA and HTB was equal to 100 mV in the studied pH range from 1 to 8 due to the CF3 of the aromatic ring of HTB mol. Due to its wider oxidation potential range, the boron doped diamond electrode was used to study the direct oxidation of TRF and ASA, as well as of their resp. metabolites HTB and SA.
Combinatorial Chemistry & High Throughput Screening published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.
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