Coles, G. C. published the artcileMechanism of action of the anthelmintic levamisole, SDS of cas: 3818-50-6, the publication is General Pharmacology (1975), 6(4), 309-13, database is CAplus.
In a solution of levamisole-HCl (I) [16595-80-5], the small round worm Nippostrongylus brasiliensis became paralyzed, but recovered on being left in the solution Both the rates of paralysis and recovery increased with increasing concentration of I. A small percentage of Ascaris suum also resumed movement in I, and were then protected against the effects of the anthelmintics bephenium hydroxynaphthoate [3818-50-6], methyridine [114-91-0], and pyrantel tartrate [33401-94-4]. The autonomic blocking agents mecamylamine and pempidine blocked I contractions in normal A. suum, and the results suggested that all 4 anthelmintics acted in a similar way.
General Pharmacology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.
Referemce:
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