Brody, Gerald published the artcileComparative activity of 29 known anthelmintics under standarized drug-diet and gavage medication regimens against four helminth species in mice, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Journal of Parasitology (1971), 57(5), 1068-77, database is CAplus and MEDLINE.
Of 29 reference anthelmintics (21 aromatic-heterocyclic and 8 organophosphate compounds) tested at an initial concentration of 1000 ppm in the diet of mice for 18 days against 4 mouse helminths, parbendazole (I) [14255-87-9] was the only compound exhibiting activity against all 4 helminths and the effectiveness of I was .sim.100% against the 4 helminths. However, in experiments using the 29 compounds at an initial dose of 200 mg/kg/day by gavage for 3 days, significant differences were observed in the effectiveness of a number of the anthelmintics in the 2 different medication regimens. The data below refers to the effectiveness of the compounds when given in the diet. Against Nematospiroides dubius, I, pyrantel (II) [15686-83-6], dl-tetramisole [5036-02-2], l-tetramisole (III) [14769-73-4], and thiabendazole (IV) [148-79-8] were the most effective. Against Hymenolepis nana (tapeworm), I and Ro-2-9009 (1,4-bis(2-diethylaminoethoxy)anthraquinone-2HCl (V) [18272-48-5] were the most effective. Against Syphacia obvelata, I, II, III, IV, V, dithiazanine (VI) [7187-55-5] (at 250 ppm), pyrvinium (VII) [7187-62-4], stilbazium (VIII) [3784-99-4], coumaphos (IX) [56-72-4], haloxon (X) [321-55-1], mercaptophos (XI) [55-38-9], and Ruelene (XII) [299-86-5] were the most effective. Against Aspiculuris tetraptera, I, II, VI, VII, VIII, IX, X, XI, XII, and dichlorvos [62-73-7] were the most effective.
Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.
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