Boltia, Shereen A. published the artcileFour validated spectrophotometric methods for determination of ambroxol, guaifenesin, and theophylline in their ternary mixture in bulk powder and dosage form, Application In Synthesis of 23828-92-4, the publication is Journal of Pharmacy Research (Mohali, India) (2018), 12(4), 446-454, database is CAplus.
The purpose of the present study was to develop and validate spectrophotometric methods for simultaneous determination of a ternary mixture of ambroxol HCl (AMB), guaifenesin (GUA) and theophylline (THEO) in pharmaceutical dosage forms. (a) Direct spectrophotometry (DS), (b) dual wavelength (DW), (c) first derivative of ratio spectra (1DD), and (d) absorption correction (AC). DS method was applied to determine AMB at its λmax (309.0 nm) without any interference of THEO and GUA. Both THEO and GUA were determined as a binary mixture after removal of AMB contribution from the ternary mixture by ratio subtraction technique. DW method was applied to determine GUA by measuring the difference in absorbance at 224.5 nm and 255.0 nm. 1DD was used to determine THEO at 295.4 nm and GUA at 236.5 nm using 14.0μg/mL GUA and 14.5μg/mL THEO as divisors, resp. AC was applied after the second derivative for determination of GUA at 239.5 nm and THEO at 239.5 nm and 266.0 nm. The methods were accurate, specific, and successfully applied for the determination of the three drugs in laboratory prepared mixtures and their combined dosage form.
Journal of Pharmacy Research (Mohali, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.
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