Bell, Mark published the artcileDiscovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1, Related Products of alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(19), 3255-3259, database is CAplus and MEDLINE.
The oral S1PR1 agonist ponesimod demonstrated substantial efficacy in a phase II clin. trial of psoriasis. Unfortunately, systemic side effects were observed, which included lymphopenia and transient bradycardia. We sought to develop a topical soft-drug S1PR1 agonist with an improved therapeutic index. By modifying ponesimod, we discovered an ester series of S1PR agonists. To increase metabolic instability in plasma we synthesized esters described as specific substrates for paraoxonase and butyrylcholinesterases, esterases present in human plasma.
Bioorganic & Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts