Lindsay, Angus published the artcileSensitivity to behavioral stress impacts disease pathogenesis in dystrophin-deficient mice, HPLC of Formula: 97-67-6, the main research area is behavioral stress mutation phenotype dystrophin; blood pressure; dystrophin; estrogen; hypothalamic pituitary adrenal axis; skeletal muscle.
Mutation to the gene encoding dystrophin can cause Duchenne muscular dystrophy (DMD) and increase the sensitivity to stress in vertebrate species, including the mdx mouse model of DMD. Behavioral stressors can exacerbate some dystrophinopathy phenotypes of mdx skeletal muscle and cause hypotension-induced death. However, we have discovered that a subpopulation of mdx mice present with a wildtype-like response to mild (forced downhill treadmill exercise) and moderate (scruff restraint) behavioral stressors. These stress-resistant mdx mice are more phys. active, capable of super-activating the hypothalamic-pituitary-adrenal and renin-angiotensin-aldosterone pathways following behavioral stress and they express greater levels of mineralocorticoid and glucocorticoid receptors in striated muscle relative to stress-sensitive mdx mice. Stress-resistant mdx mice also presented with a less severe striated muscle histopathol. and greater exercise and skeletal muscle oxidative capacity at rest. Most interestingly, female mdx mice were more phys. active following behavioral stressors compared to male mdx mice; a response abolished after ovariectomy and rescued with estradiol. We demonstrate that the response to behavioral stress greatly impacts disease severity in mdx mice suggesting the management of stress in patients with DMD be considered as a therapeutic approach to ameliorate disease progression.
FASEB Journal published new progress about Behavior. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts