Ciura, Krzesimir published the artcileAffinity of antifungal isoxazolo[3,4-b]pyridine-3(1H)-ones to phospholipids in immobilized artificial membrane (IAM) chromatography, Quality Control of 111-87-5, the main research area is IAM-HPLC; immobilized artificial membrane; isoxazolo[3,4-b]pyridin-3(1H)-one; isoxazolone.
Currently, rapid evaluation of the physicochem. parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined using the shake flash method (n-octanol/water system) or reversed phase liquid chromatog. (RP-LC), more biosimilar alternatives to classical lipophilicity measurement are currently available. One of the alternatives is immobilized artificial membrane (IAM) chromatog. The present study is a continuation of our research focused on physiochem. characterization of biol. active derivatives of isoxazolo[3,4-b]pyridine-3(1H)-ones. The main goal of this study was to assess the affinity of isoxazolones to phospholipids using IAM chromatog. and compare it with the lipophilicity parameters established by reversed phase chromatog. Quant. structure-retention relationship (QSRR) modeling of IAM retention using differential evolution coupled with partial least squares (DE-PLS) regression was performed. The results indicate that in the studied group of structurally related isoxazolone derivatives, discrepancies occur between the retention under IAM and RP-LC conditions. Although some correlation between these two chromatog. methods can be found, lipophilicity does not fully explain the affinities of the investigated mols. to phospholipids. QSRR anal. also shows common factors that contribute to retention under IAM and RP-LC conditions. In this context, the significant influences of WHIM and GETAWAY descriptors in all the obtained models should be highlighted.
Molecules published new progress about IAM-HPLC; immobilized artificial membrane; isoxazolo[3,4-b]pyridin-3(1H)-one; isoxazolone. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts