Aroulmoji, Vincent published the artcileSolution properties and the masking of unpleasant tastes of nicotine – sweetener – water mixtures, Product Details of C12H24O11, the main research area is nicotine sweetener water mixture solution unpleasant taste.
Solutions properties of sapide mols. provide fundamental information on type (hydrophobic or hydrophilic) and degree of hydration. Physico-Chem. properties like intrinsic viscosity, Apparent Sp. volume (ASV) and related parameters for bitter mol. (nicotine) and bitterness inhibitors (carbohydrate sweeteners, artificial sweeteners) and their mixtures were determined to study the role of water structure in the mechanism of unpleasant taste inhibition. The hydrophobicity of bitter mol. (nicotine) is manifested by ASV value of 0.920 cm3g-1 obtained in artificial buffered saliva (pH ≈ 8.2). Under these conditions nicotine (3-(1-methyl-2-pyrrolidinyl)pyridine) is in neutral form, the most potentially hydrophobic. Exptl. results indicate that viscometric constant (intrinsic viscosity [η], Huggins constant k’, B coefficient) could discriminate between different sapid mols. tested at our laboratory The ASV value of carbohydrate sweeteners falls within the sweet region. The bitterness of nicotine is manifested by ASV as high as 0.920 cm3g-1, which falls in the bitter region. Solution properties also determined for sweet-bitter mixtures validate an improvement in the fitting of solute mols. with solvent structure through the decrease of ASV which falls in the range of ASVs of sweet mols. The results of viscometric constants and hydration number of sweet-bitter mixtures illustrate an obvious effect of sweet mols. on the hydration property of nicotine. The effect of sweetener on the solution property of bitter mol. (nicotine) is attributed to a modification of hydration. This exptl. result validates the assumption in designating sweetener as bitterness inhibitor. The mechanism of inhibition of bitterness by sweet mols. may be credited to the arrangement of water mols. hydration which is more mobile.
International Journal of Pharmaceutical Sciences and Research published new progress about Bitterness. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts