Kong, Qiuhong published the artcileIn vitro fermentation characteristics of polysaccharide from Sargassum fusiforme and its modulation effects on gut microbiota, Synthetic Route of 59-23-4, the main research area is polysaccharide Sargassum fusiforme fermentation gut microbiota; Fermentation; Gut microbiota; Sargassum fusiforme polysaccharide (SFP); Short chain fatty acids (SCFAs); Structural characteristics.
In this study, polysaccharides from Sargassum fusiforme (SFP) were obtained by cellulase assisted hot water extraction The chem. composition, structural characteristics, and in vitro fermentation properties of SFP were investigated. Results showed that the contents of total carbohydrate, protein, uronic acid and sulfate in SFP were 83.25%, 1.42%, 12.80% and 7.81%, resp. It mainly consisted of fucose glucose and galactose, with mol. weight of 255.83 kDa. UV spectrum, FTIR, SEM and AFM results showed that SFP was a typical sulfate polysaccharide with relative smooth surface and regular shape. After in vitro fermentation for 24 h, the pH value of fermentation medium declined significantly (p < 0.05), utilization of carbohydrate was 53.17%. The contents of total SCFAs increased by 10.77 times. Moreover, SFP fermentation could change obviously the microbiota composition It significantly increased the abundance of Faecalibacterium (increased by 49.07% compared with the Blank24 group), Phascolarctobacterium (increased by 88.06%), Bifidobacterium (increased by 139.13%), Ruminococcaceae_UCG-014 (increased by 177.78%), and Lactobacillus (increased by 400.00%), decreased the abundance of Prevotella_9 (decreased by 34.54%) and Blautia (decreased by 40.79%) at genus level. These results showed that SFP could be utilized by microbiota in human feces, and may have the potential to improve intestinal health. Food and Chemical Toxicology published new progress about Agathobacter. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.
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