Kapur, S. published the artcileToxicology of benzyl alcohols: a QSAR analysis, Related Products of alcohols-buliding-blocks, the main research area is QSAR benzyl alc toxicity.
There is an evidence that benzyl alcs. may exhibit toxicity via a radical mechanism. To test this possibility, the authors studied the toxicity of para substituted benzyl alcs. on rapidly dividing cancer cells (L1210 leukemia). This system has previously found utility in studying the apparent radical toxicity of a variety of phenols. However, no evidence could be found for an electronic effect and the cellular toxicity was associated primarily with hydrophobicity. Comparison of this quant. structure-activity relationships (QSAR) with others for the reactions of benzyl alcs. in diverse systems provides insight into mechanisms of action. A QSAR for the interaction of benzyl alcs. with protozoa yields an equation that is dependent on both hydrophobicity and acidity of the OH group vs. a mixture of bacteria and fungi, the critical dependence on hydrophobicity prevails with a small dependence on a resonance-stabilized, radical mediated electronic effect. The chloramphenicols provide an instructive example, where the radical mediated electronic effect overshadows the hydrophobic contribution to bacterial toxicity. These various QSAR for benzyl alcs. indicate that mechanisms of growth inhibition in vitro vary depending on cell/organism type, the strength of the bond and lability of the hydrogen, and the strength of the initiating radical reagent.
Chemosphere published new progress about Cytotoxicity. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts