Guo, Ciliang published the artcileIsolation and structure characterization of a polysaccharide from Crataegus pinnatifida and its bioactivity on gut microbiota, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Crataegus Bacteroides Bifidobacterium polysaccharide short chain fatty acid; Bacteria competition; Crataegus pinnatifida; Gut microbiota; Polysaccharide; Short chain fatty acid.
A glucose rich heteroglycan named HAW1-2 was isolated and purified from fruit of Crataegus pinnatifida by hot-water extraction, ethanol precipitation, DEAE-cellulose anion exchange and gel permeation chromatog. HAW1-2 was proved as a homogenous polysaccharide with a mol. weight (Mw) of 8.94 kDa. Monosaccharide composition results indicated that HAW1-2 was composed of arabinose, galactose and glucose. Methylation anal. and NMR spectrum showed that HAW1-2 contained â?)-β-D-Glcp-(1â? â?)-β-D-Galp-(1â? α-L-Araf-(1â? â?)-α-L-Araf-(1â? β-D-Glcp-(1â?and â?,6)-β-D-Glcp-(1â? Bioactivity test showed that HAW1-2 could significantly promote the growth of Bacteroides thetaiotamicron (BT), Bacteroides ovatus (BO) and Bifidobacterium longum (BL), which showed competition with the Bacteroides spp. under co-culture. Interestingly, Bacteroides spp. generated more acetic acids and propionic acids while BL only generated acetic acids. These results imply that polysaccharide HAW1-2 may be useful for human by modulating intestinal bacteria and producing short chain fatty acids.
International Journal of Biological Macromolecules published new progress about Bacteroides. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
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