Yu, Juan published the artcileRelationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures, SDS of cas: 59-23-4, the main research area is Astragalus polysaccharide structure antitumor temperature; Antitumor activity; Astragalus membranaceus polysaccharides; Structural characterization.
This study investigated the effects of different temperatures on structural characterization and antitumor activity of polysaccharides from Astragalus membranaceus. APS4 and APS90 were extracted at 4°C and 90°C, resp., and purified by Sephadex G-200 column. APS4-90 were obtained from APS4 after treatment at 90°C for 6 h. MTT results showed that APS4 possessed the highest inhibitory effects on MGC-803, A549 and HepG2 cells. HPGPC anal. showed that the average mol. weights of these polysaccharides were approx. 1.5 × 106 Da, while the asym. peak of APS4-90 suggested heat degradation and configuration changes of APS4. GC, NMR and methylation results showed that these three polysaccharides had similar monosaccharide components (mainly contain glucose), and their backbones were composed of (1→2)-α-D-Glcp. However, APS4 showed higher content of (1→2,6)-α-D-Glcp compared to APS4-90 and APS90, which indicated that higher branched degree would be responsible for the stronger in vitro antitumor activity in APS4. These results were also confirmed by sp. rotation and SEM anal. Our study suggested that APS4 had the potential application for cancer treatment.
International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.
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