Uliassi, Elisa published the artcileA Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is phenothiazin synthesis psychotropic neuroprotectant blood brain barrier neurodegenerative disease; Neurodegenerative diseases; neural regeneration; neuroprotection; phenothiazines; phenotypic screening; psychotropic agents.
Overcoming the lack of effective treatments and the continuous clin. trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously neuroprotection and neuroregeneration. In the studies reported herein, we sought to identify small mols. that might exert neuroprotective and neuroregenerative potential as tools against neurodegenerative diseases. In doing so, we started from the reported neuroprotective/neuroregenerative mechanisms of psychotropic drugs featuring a tricyclic alkylamine scaffold. Thus, we designed a focused-chem. library of 36 entries aimed at exploring the structural requirements for efficient neuroprotective/neuroregenerative cellular activity, without the manifestation of toxicity. To this aim, we developed a synthetic protocol, which overcame the limited applicability of previously reported procedures. Next, we evaluated the synthesized compounds through a phenotypic screening pipeline, based on primary neuronal systems. Phenothiazine 2Bc showed improved neuroregenerative and neuroprotective properties with respect to reference drug desipramine (2Aa). Importantly, we have also shown that 2Bc outperformed currently available drugs in cell models of Alzheimer’s and Parkinson’s diseases and attenuates microglial activation by reducing iNOS expression.
ACS Chemical Neuroscience published new progress about Alzheimer disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts