Tao, Yangchun published the artcilePseudo target release behavior of simvastatin through pH-responsive polymer based on dynamic imine bonds: Promotes rapid proliferation of osteoblasts, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is simvastatin release polymer pH osteoblast cell proliferation; Controlled release; Simvastatin; Stimuli-responsive polymer; pH-responsive polymer.
In this article, a simvastatin loaded pentaerythritol tetra(3-mercaptopropionate)-allylurea-poly(ethylene glycol) (SIM-loaded PETMP-AU-PEG) polymer with excellent biocompatibility by means of in-situ loading method was synthesized. The presence of the imine bonds has given the polymer system an excellent response performance to weak acidic environment. Specifically, for the SIM-loaded polymer, the simvastatin cumulative release dose is only 2.2% in the first 2 h, and the first 32 h of the cumulative release dose is less than 10% in pH 7.4; However, in pH 6.0, the first 2 h of the cumulative release dose is 65.2%, and the first 32 h of the cumulative release dose is almost 100%. MC3T3-E1 osteoblast cell culture experiments show that the SIM-loaded polymer at pH 6.0 can accelerate the proliferation of osteoblasts significantly, which is expected to promote the rapid proliferation of bone cells in clin. applications and accelerate the healing of the lesion region.
Materials Science & Engineering, C: Materials for Biological Applications published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts