Ol’khovich, Marina published the artcileIsavuconazole: Thermodynamic Evaluation of Processes Sublimation, Dissolution and Partition in Pharmaceutically Relevant Media, Recommanded Product: n-Octanol, the main research area is isavuconazole thermodn evaluation sublimation dissolution partition pharmaceutically relevant media; Hansen solubility parameter; isavuconazole; partition; protolytic properties; solubility; sublimation; thermodynamic functions.
A temperature dependence of saturated vapor pressure of isavuconazole (IVZ), an antimycotic drug, was found by using the method of inert gas-carrier transfer and the thermodn. functions of sublimation were calculated at a temperature of 298.15 K. The value of the compound standard molar enthalpy of sublimation was found to be 138.1 ± 0.5 kJ·mol-1. The IVZ thermophys. properties-m.p. and enthalpy-equaled 302.7 K and 29.9 kJ mol-1, resp. The isothermal saturation method was used to determine the drug solubility in seven pharmaceutically relevant solvents within the temperature range from 293.15 to 313.15 K. The IVZ solubility in the studied solvents increased in the following order: buffer pH 7.4, buffer pH 2.0, buffer pH 1.2, hexane, 1-octanol, 1-propanol, ethanol. Depending on the solvent chem. nature, the compound solubility varied from 6.7 x 10-6 to 0.3 mol·L-1. The Hansen s approach was used for evaluating and analyzing the solubility data of drug. The results show that this model well-described intermol. interactions in the solutions studied. It was established that in comparison with the van’t Hoff model, the modified Apelblat one ensured the best correlation with the exptl. solubility data of the studied drug. The activity coefficients at infinite dilution and dissolution excess thermodn. functions of IVZ were calculated in each of the solvents. Temperature dependences of the compound partition coefficients were obtained in a binary 1-octanol/buffer pH 7.4 system and the transfer thermodn. functions were calculated The drug distribution from the aqueous solution to the organic medium was found to be spontaneous and entropy-driven.
Molecules published new progress about Aqueous solutions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts