Mahmoudabadi, Samane Zarei published the artcileInvestigation of COSMO-SAC model for solubility and cocrystal formation of pharmaceutical compounds, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is acetone heptane cocrystal solubility pharmaceutical.
In this study, a predictive model named COSMO-SAC was investigated in solid/liquid equilibrium for pharmaceutical compounds The examined properties were the solubility of drug in the pure and mixed solvents, octanol/water partition coefficient, and cocrystal formation. The results of the original COSMO-SAC model (COSMO-SAC (2002)) was compared with a semi-predictive model named Flory-Huggins model and a revised version of the COSMO-SAC (COSMO-SAC (2010)). The results indicated the acceptable accuracy of the COSMO-SAC (2002) in the considered scope. The results emphasized on the suitability of the COSMO-SAC model for simple mols. containing C, H, and O by covalent and hydrogen bonding interactions. Applicability of the COSMO-SAC for more complicated mols. made of various functional groups such as COO and COOH doubly requires more modification in the COSMO-SAC.
Scientific Reports published new progress about Cocrystallization. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.
Referemce:
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Alcohols – Chemistry LibreTexts