Liu, Guo published the artcileExtraction, structural characterization, and immunobiological activity of ABP Ia polysaccharide from Agaricus bisporus, Quality Control of 59-23-4, the main research area is Agaricus polysaccharide rhamnose arabinose splenocyte proliferation immunoregulatory activity; Agaricus bisporus polysaccharides; Extraction and structure; Immunobiological activity.
The extraction, purification, immunobiol. activities, and structure of Agaricus bisporus polysaccharides (ABP) were investigated. Especially we purified and identified the polysaccharides with the highest in vitro immunobiol. activity. The extraction conditions of ABP were optimized using single factor and orthogonal experiment ABP Ia was screened after double purification with DEAE-52 and Sephadex G-200 and showed the best immunoregulatory activity. UV spectra anal. and high-performance gel permeation chromatog. results indicated that the ABP Ia fraction did not contain any proteins or nucleotides and was a homogeneous polysaccharide with a relative mol. weight of 784 kDa. Gas chromatog. mass spectroscopy results showed that ABP Ia was a heteropolysaccharide consisting of ribose, rhamnose, arabinose, xylose, mannose, glucose, and galactose at a molar ratio of 2.08:4.61:2.45:22.25:36.45:89.22:1.55. FT-IR and periodic acid oxidation anal. indicated that ABP Ia was an α-pyran polysaccharide composed of 1 → 2 and 1 → 4 glycosidic bonds, as well as a possible 1 → 3 glycosidic bond. Furthermore, at. force microscopy revealed that ABP Ia polysaccharide chains twisted to form a rod-like architecture and, at a 5% concentration, aggregated into a tight structure similar to the shape of a stone forest. These findings identify ABP Ia as a potential functional food ingredient or pharmaceutical for immunoregulation.
International Journal of Biological Macromolecules published new progress about Agaricus bisporus. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.
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