Ji, Hai-yu published the artcileEffects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa, HPLC of Formula: 59-23-4, the main research area is Grifola polysaccharide antitumor agent heat treatment hepatocellular carcinoma; Antitumor; Heat treatment; Polysaccharides from Grifola frondosa; Structure.
This study investigated the effects of heat treatment on structural characteristics and in vitro antitumor activity of polysaccharides from Grifola frondosa. GFP-4 (extracted at 4°C), GFP-4-80 (80°C treatment on GFP-4) and GFP-80 (extracted at 80°C) were prepared, and the chem. composition anal. showed that their total sugar contents were all higher than 90%, high-performance gel-permeation chromatog. (HPGPC), ion chromatog. (IC) and Fourier-transform IR spectroscopy (FTIR) results demonstrated that GFP-4 were degraded and denatured after 80°C heat treatment, MTT and JC-1 results showed that GFP-4 exhibited higher inhibitory effects on HepG2 cells in vitro than GFP-4-80 and GFP-80. Our study suggested that heat treatment at 80°C on polysaccharides from Grifola frondosa would destroy their structure and attenuate their antitumor effects.
Applied Biochemistry and Biotechnology published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.
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