El-Garawani, Islam published the artcileFoeniculum Vulgare and Pelargonium Graveolens Essential Oil Mixture Triggers the Cell Cycle Arrest and Apoptosis in MCF-7 Cells, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is Foeniculum Pelargonium essential oil breast cancer cell cycle apoptosis; Fennel; GC-MS; MCF-7; anticancer; apoptosis; geranium..
This study aimed to evaluate the anticancer mechanism of fennel and geranium oils combined treatment on MCF-7 cells. The GC-MS method for essential oil characterization as well as the in vitro cytotoxicity, morphol. changes, real-time PCR and immunocytochem. investigation for apoptosis-related markers, in addition, to flow cytometric cell cycle distribution anal. were done. The major constituents of both essential oils were anethole (55.33%) and estragole (11.57%) for fennel essential oil. However, cintronellol (34.40%) and geraniol (8.67%) were identified in geranium oil. The results revealed an IC50 of 220±5.7 and 60±2.1μg/mL for fennel and geranium oils, resp. The mechanistic anticancer properties were investigated throughout the 70, 50, and 25μg/mL of oils mixture The marked apoptotic morphol. and the flow cytometric cell cycle distribution anal. in addition to the levels of apoptosisrelated makers such as p53, caspase-3, mir-21, mir-92a, Bcl-2, and ki-67 confirmed that fennel and geranium oils combination induced cell cycle arrest and apoptosis in MCF-7 cells. Moreover, the oils mixture did not exert any significant (P<0.01) toxicity on normal human peripheral blood lymphocytes in vitro. The findings showed that the mixture of oils exerted selective cytotoxicity towards MCF-7 cells through induction of cell cycle arrest and apoptosis which may be triggered by the synergistic effect between the active ingredients of fennel and geranium oils. Anti-Cancer Agents in Medicinal Chemistry published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.
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