Du, Baoxiang published the artcileIsolation, purification, structural analysis and biological activities of water-soluble polysaccharide from Glehniae radix, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Glehniae lung cancer polysaccharide antiinflammatory anticancer; Biological activities; Glehniae radix polysaccharide; Structural analysis.
A new polysaccharide named GRP (Glehniae radix polysaccharide) was isolated and purified from Glehniae radix by hot water extraction, ethanol precipitation, anion-exchange and gel-filtration chromatog. GRP was homogeneous, with a mol. weight of 1.33 × 104 Da, as determined by high-performance size-exclusion chromatog.-refractive index detector anal. Its structural characteristics were investigated and elucidated by methylation anal., gas chromatog. mass spectrometry, Fourier transform IR and NMR spectroscopy. Based on obtained data, GRP was found to be a-D-glucan containing (1-6)-linked and (1-3)-linked backbone with a branch of one (1-6)-linked and terminal glucoses submitting at the C-4 position every fourteen residues. The biol. activities of GRP upon proliferation of splenic lymphocyte, RAW264.7 cells and A549 cell, and production of nitric oxide (NO) were investigated in vitro. The results showed that GRP exhibited inhibition against A549 cells proliferation and NO production in RAW264.7 cells, and displayed promotion for proliferation of mouse spleen lymphocytes and RAW264.7 cells, which suggested that GRP may have potential immunoregulation, anti-inflammatory and anti-tumor activity.
International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.
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