Costa, Carina Pedrosa published the artcileMetabolomics profiling of human exhaled breath condensate by SPME/GC × GC-ToFMS: Exploratory study on the use of face masks at the level of lipid peroxidation volatile markers, Application In Synthesis of 124-76-5, the main research area is human EBC volatile metabolomic lipid peroxidation SPME GC ToFMS.
Metabolomics encompasses the acquisition of large-scale datasets from a single sample to identify and/or elucidate physiol. or pathol. mechanisms, or even to assess environmental exposure, being sample preparation and instrumental anal. two fundamental steps in the construction of a metabolomics workflow. The study of the human exhaled breath condensate (EBC) has gained tremendous interest recently owing to the advances in anal. techniques. Thus, this study aims to develop a methodol. for EBC metabolites profiling based on headspace solid phase microextraction (SPME) combined with comprehensive two-dimensional gas chromatog. (GC × GC). Metabolite′s extraction efficiency was improved by the optimization of four SPME parameters using a real EBC matrix: fiber coating, sample pH and volume, and extraction temperature The EBC anal. was performed according to the optimized parameters, using aliquots of 500 μL of EBC, at its physiol. pH, with the DVB/CAR/PDMS fiber coating, at 40.0 ± 0.1 °C, being able to detect analytes at pg/mL, with acceptable reproducibility. The EBC volatile composition was provided, with around 400 chem. features detected, in which 130 were putatively identified as belonging to hydrocarbons, aldehydes, alcs., ketones, esters, monoterpenic and sesquiterpenic compounds, ethers, norisoprenoids and furans, revealing therefore its high complexity. This research represents the most detailed study on the volatile composition of EBC and allows the assessment of a broad range of endogenous and exogenous metabolites, with further relevance on clin. or environmental exposure studies. To test the applicability of this methodol., an exploratory study was carried out to assess the impact of the use of surgical facemasks on young researcher′s lipid peroxidation volatile markers during a normal working day in a laboratory In young healthy adults (age ≤ 32), the use of surgical facemasks seems not significantly affect the levels of the volatile markers of lipid peroxidation (aliphatic alkanes and aldehydes), neither the O2 saturation level – SpO2. This methodol. shows promise as a convenient way to follow specific physiol. or pathol. conditions based on EBC metabolome and may be paired as part of an aggregate anal. structure.
Microchemical Journal published new progress about Adult, mammalian. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.
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