Cerofolini, Linda published the artcileSynthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs), Quality Control of 87905-98-4, the main research area is preparation PAMAM dendrimer matrix metalloproteinase inhibitor dry eye syndrome; Dendrimers; Inhibitors; Metalloproteins; NMR spectroscopy; Sulphonamidic scaffold.
Dendrimers are efficient drug delivery systems particularly useful in ocular diseases. In particular, low generation PAMAM dendrimers are non-toxic and non-immunogenic and they provide an enhancement of the residence time of drugs in the eyes. In this context, the synthesis of the PAMAM-based matrix metalloproteinases inhibitor 5, is reported. In particular, we demonstrated that 5 strongly binds (18.0 nM ± 2.5 nM) MMP-9, the most relevant MMP responsible of ocular surface damages in induced dry eyes syndrome (DES).
Bioorganic & Medicinal Chemistry published new progress about Dry eye syndrome. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Quality Control of 87905-98-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts