Bermejo, Jesus F. published the artcileWater-soluble carbosilane dendrimers: synthesis, biocompatibility and complexation with oligonucleotides; evaluation for medical applications, Related Products of alcohols-buliding-blocks, the main research area is carbosilane dendrimer biocompatibility oligonucleotide plasmid gene delivery.
Novel amine- or ammonium-terminated carbosilane dendrimers of type nG-[Si{OCH2(C6H3)-3,5-(OCH2CH2NMe2)2}]x, nG-[Si{O(CH2)2N(Me)(CH2)2NMe2}], and nG-[Si{(CH2)3NH2}]x or nG-[Si{OCH2(C6H3)-3,5-(OCH2CHNMe3+I-)2}]x, nG-[Si{O(CH2)2N(Me)(CH2)2NMe3+I-}]x, and nG-[Si{(CH2)3NH3+Cl-}]x have been synthesized and characterized up to the third generation by two strategies: (1) alcoholysis of Si-Cl bonds with amino alcs. and subsequent quaternization with MeI, and (2) hydrosilylation of allylamine with Si-H bonds of the dendritic systems and subsequent quaternization with HCL. Quaternized carbosilane dendrimers are soluble in water, although degradation is apparent due to hydrolysis of Si-O bonds. However, dendrimers containing Si-C bonds are water-stable. The biocompatibility of the second-generation dendrimers in primary cell cultures of peripheral blood mononuclear cells (PBMCs) and erythrocytes have been analyzed, and they show good toxicity profiles over extended periods. In addition, we describe a study on the interactions between the different carbosilane dendrimers and DNA oligodeoxynucleotides (ODNs) and plasmids along with a comparative anal. of their toxicity. They can form complexes with DNA ODNs and plasmids at biocompatible doses via electrostatic interaction. Also a preliminary transfection assay has been accomplished. These results demonstrate that the new ammonium-terminated carbosilane dendrimers are good base mols. to be considered for biomedical applications.
Chemistry – A European Journal published new progress about Biocompatibility. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Related Products of alcohols-buliding-blocks.
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