Zhou, Zhi-Hua published the artcileSynthesis of α-hydroxy ketones by copper(I)-catalyzed hydration of propargylic alcohols: CO2 as a cocatalyst under atmospheric pressure, Synthetic Route of 107-54-0, the main research area is hydroxy ketone preparation; propargylic alc hydration copper carbon dioxide cocatalyst.
Inexpensive and efficient Cu(I) catalysis is reported for the synthesis of α-hydroxy ketones CH3C(O)C(R1)(R2)OH [R1 = Me, Et, iso-Bu, hexyl, vinyl; R2 = Me, phenyl; R1R2 = -(CH2)5-] and 17β-hydroxyprogesterone from propargylic alcs. HCCC(R1)(R2)OH and 17β-hydroxypregn-5-en-20-yn-3-one, CO2, and water via tandem carboxylative cyclization and nucleophilic addition reaction. Notably, hydration of propargylic alcs. can be carried out smoothly under atm. CO2 pressure, generating a series of α-hydroxy ketones efficiently and selectively. This strategy shows great potential for the preparation of valuable α-hydroxy ketones by using CO2 as a crucial cocatalyst under mild conditions.
Chinese Journal of Catalysis published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Synthetic Route of 107-54-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts