Xia, Guoqin published the artcileReversing conventional site-selectivity in C(sp3)-H bond activation, SDS of cas: 584-02-1, the main research area is directing group regioselective carbon hydrogen bond activation.
One of the core barriers to developing C-H activation reactions is the ability to distinguish between multiple C-H bonds that are nearly identical in terms of electronic properties and bond strengths. Through recognition of distance and mol. geometry, remote C(sp2)-H bonds have been selectively activated in the presence of proximate ones. Yet achieving such unconventional site selectivity with C(sp3)-H bonds remains a paramount challenge. Here we report a combination of a simple pyruvic acid-derived directing group and a 2-pyridone ligand that enables the preferential activation of the distal γ-C(sp3)-H bond over the proximate β-C(sp3)-H bonds for a wide range of alc.-derived substrates [e.g., I + Me 4-iodobenzoate → II (52%, + 23% diarylated, after esterification)]. A competition experiment between the five- and six-membered cyclopalladation step, as well as kinetic experiments, demonstrate the feasibility of using geometric strain to reverse the conventional site selectivity in C(sp3)-H activation.
Nature Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts