Dai, Weiqi published the artcileOGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism, COA of Formula: C4H6O5, the main research area is hepatocellular carcinoma OGDHL glutamine metabolism; Glutamine metabolism; Liver cancer; OGDHL; Tricarboxylic acid cycle.
We systematically investigated the role of oxoglutarate dehydrogenase-like (OGDHL), one of the rate-limiting components of the key mitochondrial multi-enzyme OGDH complex (OGDHC), in the regulation of lipid metabolism in hepatoma cells and mouse xenograft models. Promoter hypermethylation and DNA copy deletion of OGDHL were independently correlated with reduced OGDHL expression in HCC specimens. Addnl., OGDHL overexpression significantly inhibited the growth of hepatoma cells in mouse xenografts, while knockdown of OGDHL promoted proliferation of hepatoma cells. Notably, silencing of OGDHL activated the mTORC1 signaling pathway in an αKG-dependent manner, inducing transcription of enzymes with key roles in de novo lipogenesis. Meanwhile, metabolic reprogramming in OGDHL-neg. hepatoma cells provided an abundant supply of NADPH and glutathione to support the cellular antioxidant system. OGDHL is a promising prognostic biomarker and therapeutic target for HCC. Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide and is correlated with a high mortality rate. In patients with HCC, lower expression of the enzyme OGDHL is significantly associated with worse survival. Herein, we show that silencing of OGDHL induces lipogenesis and influences the chemosensitization effect of sorafenib in liver cancer cells by reprogramming glutamine metabolism OGDHL is a promising prognostic biomarker and potential therapeutic target in OGDHL-neg. liver cancer.
Journal of Hepatology published new progress about Biomarkers. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.
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