Briz-Cid, Noelia published the artcileInfluence of tetraconazole on the proteome profile of Saccharomyces cerevisiae Lalvin T73 strain, Application of 3-(Methylthio)propan-1-ol, the main research area is proteome grape wine tetraconazole stress response Saccharomyces; Amino acid and purine biosynthesis; Ergosterol biosynthesis; Multidrug resistance; Proteome profile; Putative transcription factors; Stress response.
This work aimed to evaluate the modifications on the proteome profile of Saccharomyces cerevisiae T73 strain as a consequence of its adaptive response to the presence of tetraconazole mols. in the fermentation medium. Pasteurised grape juices were sep. supplemented with tetraconazole or a com. formulation containing 12.5% w/v of tetraconazole at two concentration levels. In addition, experiments without fungicides were developed for comparative purposes. Proteome profiles of yeasts cultured in the presence or absence of fungicide mols. were different. Independently of the fungicide treatment applied, the highest variations concerning the control sample were observed for those proteins involved in metabolic processes, especially in the metabolism of nitrogen compounds Tetraconazole mols. altered the abundance of several enzymes involved in the biosynthesis of amino acids, purines, and ergosterol. Moreover, differences in the abundance of several enzymes of the TCA cycle were found. Changes observed were different between the active substance and the com. formulation. The presence of fungicide residues in grape juice has direct implications on the development of the aromatic profile of the wine. These alterations could be related to changes in the secondary metabolism of yeasts. However, the mol. mechanisms involved in the response of yeasts to fungicide residues remains quite unexplored. Through this exhaustive proteomic study, alterations in the amino acids biosynthesis pathways due to the presence of the tetraconazole mols. were observed Amino acids are precursors of some important higher alcs. and Et acetates (such as methionol, 2-phenylethanol, isoamyl alc. or 2-phenylacetate). Besides, the effect of tetraconazole on the ergosterol biosynthesis pathway could be related to a higher production of medium-chain fatty acids and their corresponding Et acetates.
Journal of Proteomics published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application of 3-(Methylthio)propan-1-ol.
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