New 1-hetarylfuropyridines and chromenes based on pyridoxal and 4-hydroxycoumarin was written by Trifonov, Alexey V.;Kibardina, Lyudmila K.;Dobrynin, Alexey B.;Akhunov, Amirjon A. Ali;Pudovik, Mikhail A.;Burilov, Alexander R.. And the article was included in Mendeleev Communications in 2020.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:
Pyridoxal in the absence of a catalyst forms furo[3,4-c]pyridine species (ortho aldehyde and hydroxymethyl groups were involved) which is further transformed into C-C hybrid with 4-hydroxycoumarin. Different products of chromeno[3′,4′:5,6]pyrano[2,3-c]pyridine type were formed when pyridoxal hydrochloride or more sophisticated 2,4-dihydroxybenzaldehyde derivative were applied (herein, ortho aldehyde and hydroxy groups were involved into heterocyclization). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C8H10ClNO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts