Synthesis of Chiral Endocyclic Allenes by Palladium-Catalyzed Asymmetric Annulation Followed by Cope Rearrangement was written by Shi, Bin;Liu, Jia-Bin;Wang, Ze-Tian;Wang, Liang;Lan, Yu;Lu, Liang-Qiu;Xiao, Wen-Jing. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:
Catalytic asym. synthesis of chiral endocyclic allenes remains a challenge in allene chem. owing to unfavored tension and complex chirality. Here,a new relay strategy merging Pd-catalyzed asym. [3+2] annulation with enyne-Cope rearrangement, providing a facile route to chiral 9-membered endocyclic allenes with high efficiency and enantioselectivity was presented. Moreover, theor. calculations and exptl. studies were performed to illustrate the critical, but unusual Cope rearrangement that allows for the complete central-to-axial chirality transfer. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate
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