Continuous flow Reductive Alkylation of Methanol by Aldehydes. Synthesis of O-Methyl Ethers and 1,1-Dimethoxyacetals was written by Radjagobalou, Robbie;Rouffeteau, Virgile;Deleu, Alexia;Nabokoff, Pierre;Cossy, Janine;Len, Christophe. And the article was included in Molecular Catalysis in 2022.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:
A mild and efficient continuous-flow catalytic reductive alkylation of methanol by various linear and branched aliphatic aldehydes, at 140°C, using a Pd/C cartridge (1 wt% – 5 wt%) under 1 bar of hydrogen, was developed to produce O-Me ethers in high yields and tolyl derivatives from aryl aldehydes. When the pourcentage of Pd/C was lower than 1 wt%, 1,1-dimethoxyacetals were obtained from aldehydes. To rationalize these results, a mechanism was proposed. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).
3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 3,7-Dimethyloctan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts