High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles was written by Kritchenkov, Andreii S.;Kurasova, Margarita N.;Godzishevskaya, Anastasia A.;Mitrofanova, Elizaveta S.;Egorov, Anton R.;Yagafarov, Niyaz Z.;Ballesteros Meza, Moises J.;Tskhovrebov, Alexander G.;Artemjev, Alexey A.;Andrusenko, Elena V.;Khrustalev, Victor N.. And the article was included in Mendeleev Communications in 2021.Reference of 65-22-5 The following contents are mentioned in the article:
The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-mol.-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate mol. weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts