Synthesis of 1-(hydroxyaryl)furo[3,4-c]pyridines from 1-amino(alkoxy)furo[3,4-c]pyridines and (poly)phenols was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Mikhail A.;Burilov, Alexander R.. And the article was included in Mendeleev Communications in 2018.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:
The herein obtained 1-diethylamino-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol or its 1-ethoxy analog in their reactions with phenols or polyphenols undergo replacement of Et2N/OEt groups with (poly)hydroxyaryl moieties. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts