Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis was written by Baker, Stephen J.;Zhang, Yong-Kang;Akama, Tsutomu;Lau, Agnes;Zhou, Huchen;Hernandez, Vincent;Mao, Weimin;Alley, M. R. K.;Sanders, Virginia;Plattner, Jacob J.. And the article was included in Journal of Medicinal Chemistry in 2006.Electric Literature of C7H6BFO2 The following contents are mentioned in the article:
A structure-activity relationship investigation for a more efficacious therapy to treat onychomycosis, a fungal infection of the toe and fingernails, led to the discovery of a boron-containing small mol., AN2690 (I), which is currently in clin. trials for onychomycosis topical treatment. This study involved multiple reactions and reactants, such as 7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3Electric Literature of C7H6BFO2).
7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C7H6BFO2
Referemce:
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