Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors was written by Aronov, Alex M.;Baker, Christopher;Bemis, Guy W.;Cao, Jingrong;Chen, Guanjing;Ford, Pamella J.;Germann, Ursula A.;Green, Jeremy;Hale, Michael R.;Jacobs, Marc;Janetka, James W.;Maltais, Francois;Martinez-Botella, Gabriel;Namchuk, Mark N.;Straub, Judy;Tang, Qing;Xie, Xiaoling. And the article was included in Journal of Medicinal Chemistry in 2007.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol The following contents are mentioned in the article:
The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p(I), a potent and selective inhibitor of ERK. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol).
(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts