The influence of fluorine position on the properties of fluorobenzoxaboroles was written by Adamczyk-Wozniak, Agnieszka;Cabaj, Malgorzata K.;Dominiak, Paulina M.;Gajowiec, Patrycja;Gierczyk, Blazej;Lipok, Jacek;Popenda, Lukasz;Schroeder, Grzegorz;Tomecka, Ewelina;Urbanski, Piotr;Wieczorek, Dorota;Sporzynski, Andrzej. And the article was included in Bioorganic Chemistry in 2015.COA of Formula: C7H6BFO2 The following contents are mentioned in the article:
5-Fluoro-2,1-benzoxaborol-1(3H)-ol, a potent antifungal drug also known as Tavaborole or AN2690, has been compared with its three isomers in terms of its activity against several fungi as well as pKa and multinuclear NMR characterization. The mol. and crystal structure of 6-fluoro-2,1-benzoxaborol-1(3H)-ol was determined and compared with that of AN2690. This study involved multiple reactions and reactants, such as 7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3COA of Formula: C7H6BFO2).
7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol (cas: 174671-93-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H6BFO2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts