Zhou, Yulu published the artcilePhotocatalytic Sulfonylcarbocyclization of Alkynes Using SEt as a Traceless Directing Group: Access to Cyclopentenes and Indenes, HPLC of Formula: 107-54-0, the main research area is cyclopentene indene preparation regioselective; alkyne sodium sulfinate photocatalytic Sulfonylcarbocyclization; 5-endo-trig cyclization; C−H functionalization; alkyne; photocatalysis; radical.
Herein, a traceless directing group strategy was designed to reverse the regioselectivity of radical addition which enabled an unprecedented photocatalytic sulfonylcarbocyclization of terminal alkynes by forming C-C bond on inert C(sp3)-H bond. It offered a facile access to decorated cyclopentenes and indenes under mild conditions. The resultant products could be converted into a set of valuable mol. scaffolds, including a key intermediate of AM-6226. Mechanistic experiments suggested a radical cascade pathway comprising a Markovnikov-type sulfonylation, 1,5-hydrogen atom transfer, 5-endo-trig cyclization, and β-elimination. This study lays further groundwork for the use of anti-Baldwin 5-endo-trig radical cyclization in rapidly assembling five-membered carbocycles.
Angewandte Chemie, International Edition published new progress about Cyclization (sulfonylcarbocyclization). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, HPLC of Formula: 107-54-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts