Zheng, Yuzhu published the artcileDirect activation of alcohols via perrhenate ester formation for an intramolecular dehydrative Friedel-Crafts reaction, Related Products of alcohols-buliding-blocks, the main research area is silica supported rhenium oxide preparation; tetrahydronaphthalene derivative preparation; aryl alc intramol dehydrative Friedel Crafts rhenium oxide catalyst.
A general method for synthesis of tetrahydronaphthalene derivatives I [R = Ph, 4-MeC6H4, 2-BrC6H4, etc.; R1 = H, Me; R2 = H, 5-Me, 7-Br, etc.; X = CH2, O, NTs; Y = CH2, O, NTs] via Re2O7 catalyzed intramol. dehydrative Friedel-Crafts reaction of alcs. in hexafluoroisopropanol (HFIP) was reported. The potential application of this methodol. was exemplified by the formal or total synthesis of several com. available drugs or biol. relevant mols., including sertraline, nafenopin, etc. DFT calculations showed the preference for the activation of hydroxyl groups by Re2O7 via perrhenate ester formation followed by heterolytic C-O bond cleavage over Bronsted acid-catalyzed dehydration.
Organic Chemistry Frontiers published new progress about Free energy. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts