Wang, Ye published the artcileEnantioselective Desymmetrization of Bisphenol Derivatives via Ir-Catalyzed Allylic Dearomatization, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is bisphenol iridium allylic dearomatization catalyst; spirocyclic hexadienone stereoselective preparation.
Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone derivatives with up to three contiguous stereogenic centers in good yields (up to 90%) and excellent enantioselectivity (up to 99% ee). The high efficiency of this reaction is exemplified by the short reaction time (30 min), low catalyst loading (down to 0.2 mol %), and ability to perform the reaction on a gram-scale. The total syntheses of (+)-tatanan B and (+)-tatanan C were also realized using this Ir-catalyzed allylic dearomatization reaction as a key step.
Journal of the American Chemical Society published new progress about Dearomatization (Allylic). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.
Referemce:
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