Wang, Fang published the artcileDirect Benzylic C(sp3)-O Coupling with Alcohol via Site-Selective C(sp3)-H Cleavage at Room Temperature through a Remote Directing Group-Enabled Radical Relay Strategy, Quality Control of 584-02-1, the main research area is benzylic carbon oxygen coupling alc regioselective copper catalyst; alkyl aryl carbamate carbon hydrogen bond cleavage.
Employing a low loading of the terminal oxidant, a remote directing group-enabled radical relay strategy for benzylic direct C(sp3)-H alkoxylation with alcs. at room temperature is developed. Satisfactory site-selectivity, chemoselectivity, and reaction scope are achieved under simple and mild conditions, and no ligand or additive is required. Mechanistic studies, ready conversions of the directing group, and other benzylic functionalizations currently under development in laboratory further indicate the promising potentials of this remote directing group-enabled radical relay strategy.
Journal of Organic Chemistry published new progress about Alkoxylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts