Wagner, Karl G. published the artcileFrom hot stage microscopy to hot melt extrusion – approaches to predict product performance, stability and processability, Formula: C12H24O11, the main research area is drug formulation hot melt extrusion stage microscopy computational model.
There are many drug delivery technologies that may enhance the bioavailability of a poorly water soluble drug. The ranking of the solubilization technologies is a balance between performance (both in vitro and in vivo) and efforts/costs necessary to implement the technol. In order to minimize front loading, i.e. resources expenditure prior to the selection of a front runner technol., an effective and predictive selection process needs to be in place. For hot melt extrusion (HME) this selection process can start with a micro scale performance evaluation on a hot stage microscope (HSM). A batch size of 400 mg can provide sufficient materials to assess drug product attributes like solid state properties, solubility enhancement and phys. stability as well as process related attributes such as processing temperature in a twin screw extruder (TSE). Prototype formulations will then be fed into a 5 mm TSE (apparatus 1-2 g) to confirm performance from the h SM under addnl. shear stress. Small stress stability testing might be performed with these samples or a larger batch (20-40 g) made by the 9 or 12 mm TSE. Simultaneously, numeric process simulations are performed using process data and rheol. and thermal properties of the formulations. Further scale up work to 16 mm and 18 mm TSE confirmed and refined the simulation model. Thus at the end of lab scale development, not only the clin. trial supply is manufactured but also one can form a sound risk assessment to support further scale up even without decades of process experience.
Bulletin Technique Gattefosse published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts