Schiffner, Julia A. published the artcileEnantioselective Fujiwara-Moritani Indole and Pyrrole Annulations Catalyzed by Chiral Palladium(II)-NicOx Complexes, SDS of cas: 50966-69-3, the main research area is pyridinecarboxylate oxazolinyl preparation chiral ligand Fujiwara Moritani annulation; indole pyrrole alkenyl preparation asym intramol Fujiwara Moritani cyclization.
The catalytic asym. Fujiwara-Moritani ring closures of several indole- and pyrrole-based cyclization precursors, e.g. I (R1 = H, R12 = benzo; X = CH2, CH2CH2; R2 = Me, Ph), are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chem. yields. The preparation of these NicOx ligands II (R3 = i-Pr, t-Bu, PhCH2; R4 = Me, Et, F3CCH2) as well as the syntheses of the cyclization precursors, e.g. I, are described in detail.
European Journal of Organic Chemistry published new progress about Cyclization catalysts, stereoselective. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, SDS of cas: 50966-69-3.
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