Neinast, Michael D. published the artcileQuantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is cardiac skeletal muscle branched chain amino acid oxidation insulin; branched chain amino acids; insulin resistance; obesity; stable isotope tracing.
Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic diseases, including cancer, diabetes, and heart failure. However, an integrated understanding of whole-body BCAA metabolism remains lacking. Here, we employ in vivo isotopic tracing to systemically quantify BCAA oxidation in healthy and insulin-resistant mice. We find that most tissues rapidly oxidize BCAAs into the tricarboxylic acid (TCA) cycle, with the greatest quantity occurring in muscle, brown fat, liver, kidneys, and heart. Notably, pancreas supplies 20% of its TCA carbons from BCAAs. Genetic and pharmacol. suppression of branched-chain alpha-ketoacid dehydrogenase kinase, a clin. targeted regulatory kinase, induces BCAA oxidation primarily in skeletal muscle of healthy mice. While insulin acutely increases BCAA oxidation in cardiac and skeletal muscle, chronically insulin-resistant mice show blunted BCAA oxidation in adipose tissues and liver, shifting BCAA oxidation toward muscle. Together, this work provides a quant. framework for understanding systemic BCAA oxidation in health and insulin resistance.
Cell Metabolism published new progress about Blood plasma. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts