Fall, Fanta published the artcileMetabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt, Category: alcohols-buliding-blocks, the main research area is LM tryptophan metabolism lipopolysaccharide aspartate arginosuccinate metabolic reprogramming.
The objective of the present work was to characterize the metabolic alterations occurring during the exptl. M1 LM polarization. Human LM were obtained from resected lungs and cultured for 24 h in medium alone or with 10 ng.mL-1 lipopolysaccharide. Cells and culture supernatants were subjected to extraction for metabolomic anal. with high-resolution LC-MS (HILIC and reverse phase -RP- chromatog. in both neg. and pos. ionization modes) and GC-MS. The data were analyzed with R and the Worklow4Metabolomics and MetaboAnalyst online infrastructures. A total of 8,741 and 4,356 features were detected in the intracellular and extracellular content, resp., after the filtering steps. Pathway anal. showed involvement of arachidonic acid metabolism, tryptophan metabolism and Krebs cycle in the response of LM to LPS, which was confirmed by the specific quantitation of selected compounds This refined anal. highlighted a regulation of the kynurenin pathway as well as the serotonin biosynthesis pathway, and an involvement of aspartate-arginosuccinate shunt in the malate production Macrophages M1 polarization is accompanied by changes in the cell metabolome, with the differential expression of metabolites involved in the promotion and regulation of inflammation and antimicrobial activity. The anal. of this macrophage immunometabolome may be of interest for the understanding of the pathophysiol. of lung inflammatory disesases.
PLoS One published new progress about Homo sapiens. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.
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