Chen, Yu-Lan published the artcileFour-component defluorinative reaction of allylic fluorides, amidines, and Cs2CO3 under transition-metal-free conditions, Name: 3,5-Dimethylhex-1-yn-3-ol, the main research area is hydroxy iodoperfluorobutene amidine cesium carbonate tandem defluorinative heterocyclization; pyrimidinylmethyl iminomethyl carbamate preparation green chem.
An unprecedented four-component defluorinative reaction of allylic fluorides, amidines, and Cs2CO3 for the convenient synthesis of valuable pyrimidine-containing amidino carbamates under transition-metal-free conditions was reported. The synthetic linchpin for realizing the multi-bonding tandem protocol relied on the directed function of the α-positioned hydroxyl group and the activating effect of the perfluoroalkyl substituent in allylic fluorides. Moreover, cesium carbonate served as a green carbonyl equivalent for formal CO capture. Mechanistic studies revealed that the reaction proceeded via a possible cyclic carbonate intermediate.
Green Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Name: 3,5-Dimethylhex-1-yn-3-ol.
Referemce:
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Alcohols – Chemistry LibreTexts