Zhang, Tianhui’s team published research in Polymer Chemistry in 8 | CAS: 25240-59-9

Polymer Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C10H10O2, Computed Properties of 25240-59-9.

Zhang, Tianhui published the artcileSynthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery, Computed Properties of 25240-59-9, the publication is Polymer Chemistry (2017), 8(40), 6209-6216, database is CAplus.

Stimuli-responsive drug delivery systems (DDSs) offering spatial-temporal and dosage controlled transport of drugs in vivo have attracted much attention for anticancer drug delivery. In the present work, a kind of phenylboronic ester-linked PEG-lipid conjugate was designed and synthesized for H2O2-responsive drug delivery. Firstly, a chain-end alkynyl functionalized methoxy poly(ethylene glycol) with a phenylboronic pinacol ester linker was synthesized via a classical Passerini reaction of carboxyl functionalized methoxy poly(ethylene glycol)2000 (mPEG2k-COOH), 4-formylphenylboronic pinacol ester and propargyl isocyanoacetamide. The obtained polymer was denoted as mPEG2k-PBPE-alkynyl. Then, the oxidation-responsive cleavage of the phenylboronic pinacol ester linker between the mPEG2k-COOH and alkynyl chain-end was verified by in situ1H NMR and mass spectra characterization. Furthermore, the amphiphilic PEG-lipid conjugate was synthesized by the Cu(I)-catalyzed click reaction of mPEG2k-PBPE-alkynyl and 3-azido-1,2-propanediol distearate (N3-DSA). The resultant mPEG2k-PBPE-DSA could self-assemble into stable micelles in aqueous media. Nile red was used as the model drug and was loaded into the micelles. The obtained drug loaded micelles exhibited a typical H2O2-responsive drug release behavior and could be effectively internalized by MCF-7 cells. In addition, the synthesized mPEG2k-PBPE-DSA was tested to be nontoxic towards RAW264.7 cells. Therefore, this biocompatible mPEG2k-PBPE-DSA conjugate would be promising for applications in ROS-responsive drug delivery.

Polymer Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C10H10O2, Computed Properties of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts