Zhang, Dawei published the artcileAn efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Monatshefte fuer Chemie (2016), 147(9), 1605-1614, database is CAplus.
An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, Et acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86-96 %), and were characterized by HRMS, FTIR, 1H NMR, and 13C NMR spectroscopy. Solid support SiO2 possesses favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO2. Moreover, the crystal structure of compound di-Et 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented.
Monatshefte fuer Chemie published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C6H6N2O, Safety of 3-(2-Chlorophenyl)-5-isoxazolemethanol.
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